Fabrication of a pH-Responsive Magnetic Nanocarrier Based on Carboxymethyl Cellulose-Aminated Graphene Oxide for Loading and In-Vitro Release of Curcumin

In this study, a pH-responsive magnetic drug delivery system was prepared by cross-linking of Cofe2O4/graphene oxide to carboxymethyl cellulose (CMC) biopolymer with adipic acid dihydrazide (ADH) and then investigated for loading release poorly water-soluble anti-cancer drug, curcumin (CUR). The CoFe2O4/GO-ADH-CMC bio-nanocomposite characterized FE–SEM/EDX, TEM, FT–IR, XRD, TGA, VSM, zeta-potential techniques. highest amount achieved as 23.7 mg g–1 at 323 K, pH 6.0, 120 L–1 CUR concentration. study adsorption isotherms revealed that the Sips model best fitted equilibrium data (R2 > 0.997 RMSE < 0.48), which indicated contribution both chemisorption physisorption in loading. Furthermore, profile from drug-loaded studied mimicking endosomal (pH = 5.6) physiological 7.4) conditions. After 24 h, maximum cumulative releases were found be 86 38% 5.6 7.4, respectively. Also, Peppas-Sahlin kinetic followed data. MTT assay exhibited good biocompatibility CoFe2O4/GO-ADH-CMC. results implied might utilized potentially safe carrier continuous slow CUR.